Reference: Ohno-Machado, L.; Parra, E.; Henry, S. B.; Tu, S. W.; & Musen, M. A. AIDS2: A Decision-Support Tool for Decreasing Physicians' Uncertainty Regarding Patient Eligibility for HIV Treatment Protocols. Washington D.C., 1993.
Abstract: We have developed a decision-support tool, the AIDS Intervention Decision-Support System (AIDS2), to assist in the task of matching patients to therapy-related research protocols. The purposes of AIDS2 are to determine the initial eligibility status of HIV-infected patients for therapy-related research protocols and to suggest additional data-gathering activities that will decrease uncertainty related to the eligibility status. AIDS2 operates in either a patient-driven or protocol-driven mode. We represent the system knowledge in three combined levels: a classification level, where deterministic knowledge is represented; a belief-network level, where probabilistic knowledge is represented; and a control level, where knowledge about the system's operation is stored. To determine whether the design specifications were met, we presented a series of 10 clinical cases based on actual patients to the system. AIDS2 provided meaningful advice in all cases.
Notes: april Updated August 1993.
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